BDBM109865 US8609647, 25::US8609647, 3::US8609647, 59

SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=YBSXGRXZZZBXRI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 109865   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109865(US8609647, 25 | US8609647, 3 | US8609647, 59)
Affinity DataIC50:  10nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109865(US8609647, 25 | US8609647, 3 | US8609647, 59)
Affinity DataIC50:  230nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109865(US8609647, 25 | US8609647, 3 | US8609647, 59)
Affinity DataIC50:  38nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109865(US8609647, 25 | US8609647, 3 | US8609647, 59)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human Lck using TK-substrate-biotin as substrate incubated for 60 mins in presence of AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109865(US8609647, 25 | US8609647, 3 | US8609647, 59)
Affinity DataIC50:  38nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109865(US8609647, 25 | US8609647, 3 | US8609647, 59)
Affinity DataIC50:  38nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM109865(US8609647, 25 | US8609647, 3 | US8609647, 59)
Affinity DataIC50:  2.20nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent