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BDBM110676 US8614234, 144::US9725433, 144

SMILES: Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ccc[nH]3)cc2)c1

InChI Key: InChIKey=NWPTXSZKCKXBNX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 110676   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM110676
PNG
(US8614234, 144 | US9725433, 144)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ccc[nH]3)cc2)c1
Show InChI InChI=1S/C23H19FN4O2/c1-15-4-9-19(24)21(13-15)28-23(29)27-16-5-7-17(8-6-16)30-18-10-12-26-22(14-18)20-3-2-11-25-20/h2-14,25H,1H3,(H2,27,28,29)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 26n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9725433 (2017)


Article DOI: 10.1021/jm0494826
BindingDB Entry DOI: 10.7270/Q2ZP4875
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM110676
PNG
(US8614234, 144 | US9725433, 144)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ccc[nH]3)cc2)c1
Show InChI InChI=1S/C23H19FN4O2/c1-15-4-9-19(24)21(13-15)28-23(29)27-16-5-7-17(8-6-16)30-18-10-12-26-22(14-18)20-3-2-11-25-20/h2-14,25H,1H3,(H2,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 26n/an/an/an/a7.225



Allergan, Inc.

US Patent


Assay Description
Kinase assays were performed in 96 well microtiter plates that were coated overnight with 30.mu.g of poly-Glu-Tyr (4:1) in 10 mM Phosphate Buffered S...


US Patent US8614234 (2013)


BindingDB Entry DOI: 10.7270/Q20Z71XF
More data for this
Ligand-Target Pair