BDBM111701 US8618111, E-1

SMILES CN(C)C(=O)CC1CCN(CC1)c1ncnc(C)c1C#Cc1ccc(N)nc1

InChI Key InChIKey=MDIVDEHECSJESI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 111701   

TargetSerine/threonine-protein kinase mTOR(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111701(US8618111, E-1)
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111701(US8618111, E-1)
Affinity DataIC50: 54nMpH: 7.5 T: 2°CAssay Description:PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
US Patent