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BDBM112340 US8623889, 339

SMILES: Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(n1)-c1ccnn1C

InChI Key: InChIKey=TZFHXDXRZWOPSJ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112340   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM112340
PNG
(US8623889, 339)
Show SMILES Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(n1)-c1ccnn1C
Show InChI InChI=1S/C23H20FN5O/c1-13-3-6-16(24)10-17(13)19-9-15-12-25-21(28-23(30)14-4-5-14)11-18(15)22(27-19)20-7-8-26-29(20)2/h3,6-12,14H,4-5H2,1-2H3,(H,25,28,30)
PDB
MMDB

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PC sid
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Similars

US Patent
0.300n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Using the following procedure, varying concentration of compounds of the invention were assessed for their ability to inhibit c-Abl enzyme's phos...


US Patent US8623889 (2014)


BindingDB Entry DOI: 10.7270/Q2JQ0ZNX
More data for this
Ligand-Target Pair