BDBM112570 US8618103, I-66

SMILES CN(C)S(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1

InChI Key InChIKey=IKOVYVZQLUHKRJ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112570   

TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112570(US8618103, I-66)
Affinity DataKi:  0.0239nM IC50: 0.0478nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112570(US8618103, I-66)
Affinity DataIC50: 0.112nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent