BindingDB logo
myBDB logout

BDBM112736 US8629141, 2

SMILES: O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21

InChI Key: InChIKey=HQXQIUHXDOQUSV-WRXOIQOJNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112736   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112736
PNG
(US8629141, 2)
Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1/C28H30Cl2FN3O3/c29-15-6-11-19-21(14-15)33-26(37)28(19)22(18-4-3-5-20(30)23(18)31)24(34-27(28)12-1-2-13-27)25(36)32-16-7-9-17(35)10-8-16/h3-6,11,14,16-17,22,24,34-35H,1-2,7-10,12-13H2,(H,32,36)(H,33,37)/t16?,17-,22-,24+,28+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 41.8n/an/an/an/an/an/a



University of Michigan

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair