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BDBM112755 US8629141, 25

SMILES: CS(=O)(=O)CCN1CCC(CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21

InChI Key: InChIKey=DJKVIZGHBJETHE-QYEZXCNMNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112755   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112755
PNG
(US8629141, 25)
Show SMILES CS(=O)(=O)CCN1CCC(CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1/C31H37Cl2FN4O4S/c1-43(41,42)17-16-38-14-10-20(11-15-38)35-28(39)27-25(21-6-5-7-23(33)26(21)34)31(30(37-27)12-3-2-4-13-30)22-9-8-19(32)18-24(22)36-29(31)40/h5-9,18,20,25,27,37H,2-4,10-17H2,1H3,(H,35,39)(H,36,40)/t25-,27+,31+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University of Michigan

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair