BDBM112774 US8629135, SW-01

SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1\c2ccccc2-[#6]=[#6]-c2ccccc-12

InChI Key InChIKey=JURKNVYFZMSNLP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 112774   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Queen'S University At Kingston

US Patent
LigandPNGBDBM112774(US8629135, SW-01)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM112774(US8629135, SW-01)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM112774(US8629135, SW-01)
Affinity DataIC50:  1.07E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed