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BDBM113509 US8633204, 231

SMILES: Cc1nc(N)nc2n(C3CCCC3)c(=O)c(cc12)-c1cccc(Cl)n1

InChI Key: InChIKey=ZXICMWVHOQEEBU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 113509   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM113509
PNG
(US8633204, 231)
Show SMILES Cc1nc(N)nc2n(C3CCCC3)c(=O)c(cc12)-c1cccc(Cl)n1
Show InChI InChI=1S/C18H18ClN5O/c1-10-12-9-13(14-7-4-8-15(19)22-14)17(25)24(11-5-2-3-6-11)16(12)23-18(20)21-10/h4,7-9,11H,2-3,5-6H2,1H3,(H2,20,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 170n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair