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BDBM115249 US8637500, 56

SMILES: COCC1CCN(CC1)c1cccnc1Oc1ccc(Nc2ccccn2)cc1

InChI Key: InChIKey=WFOYDCDUWQKBAV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 115249   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115249
PNG
(US8637500, 56)
Show SMILES COCC1CCN(CC1)c1cccnc1Oc1ccc(Nc2ccccn2)cc1
Show InChI InChI=1S/C23H26N4O2/c1-28-17-18-11-15-27(16-12-18)21-5-4-14-25-23(21)29-20-9-7-19(8-10-20)26-22-6-2-3-13-24-22/h2-10,13-14,18H,11-12,15-17H2,1H3,(H,24,26)
PDB
MMDB

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Similars

US Patent
n/an/a 307n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair