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BDBM115291 US8637500, 100

SMILES: CC(C)CNc1nccnc1Oc1ccc(Nc2ccccn2)cc1

InChI Key: InChIKey=BTEQBLZHCLSRGE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 115291   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115291
PNG
(US8637500, 100)
Show SMILES CC(C)CNc1nccnc1Oc1ccc(Nc2ccccn2)cc1
Show InChI InChI=1S/C19H21N5O/c1-14(2)13-23-18-19(22-12-11-21-18)25-16-8-6-15(7-9-16)24-17-5-3-4-10-20-17/h3-12,14H,13H2,1-2H3,(H,20,24)(H,21,23)
PDB
MMDB

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Similars

US Patent
n/an/a 603n/an/an/an/an/a25



Amgen Inc

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair