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BDBM115293 US8637500, 102

SMILES: C(CN1CCCCC1)Nc1nccnc1Oc1ccc(Nc2ccccn2)cc1

InChI Key: InChIKey=QHNXQDBGQQVWGT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 115293   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115293
PNG
(US8637500, 102)
Show SMILES C(CN1CCCCC1)Nc1nccnc1Oc1ccc(Nc2ccccn2)cc1
Show InChI InChI=1S/C22H26N6O/c1-4-15-28(16-5-1)17-14-25-21-22(26-13-12-24-21)29-19-9-7-18(8-10-19)27-20-6-2-3-11-23-20/h2-3,6-13H,1,4-5,14-17H2,(H,23,27)(H,24,25)
PDB
MMDB

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PC sid
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Similars

US Patent
n/an/a 5.32E+3n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair