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BDBM115548 US8637500, 431

SMILES: O=C(NC(C#N)c1ccccc1)c1cccnc1Oc1ccc(Nc2ccccn2)cc1

InChI Key: InChIKey=RYCWIVVTYQPUGA-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 115548   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM115548
PNG
(US8637500, 431)
Show SMILES O=C(NC(C#N)c1ccccc1)c1cccnc1Oc1ccc(Nc2ccccn2)cc1
Show InChI InChI=1/C25H19N5O2/c26-17-22(18-7-2-1-3-8-18)30-24(31)21-9-6-16-28-25(21)32-20-13-11-19(12-14-20)29-23-10-4-5-15-27-23/h1-16,22H,(H,27,29)(H,30,31)
PDB
MMDB

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Similars

US Patent
n/an/a 442n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...


US Patent US8637500 (2014)


BindingDB Entry DOI: 10.7270/Q2XP73MV
More data for this
Ligand-Target Pair