BDBM116035 US8633183, E-184

SMILES CCc1ncnc(-c2ccc(C(=O)N3CCC(CC3)N3CCN(C)CC3)c(F)c2)c1C#Cc1ccc(NC)nc1

InChI Key InChIKey=JPQWQIBWNOVKTP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 116035   

TargetSerine/threonine-protein kinase mTOR(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 116035BDBM116035(US8633183, E-184)
Affinity DataIC50: 2.81nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 116035BDBM116035(US8633183, E-184)
Affinity DataIC50: 399nMAssay Description:PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent