BindingDB PrimarySearch

BDBM11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US11786535, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662

SMILES: Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F

InChI Key: InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N

Data: 152 KI 641 IC50 2 Kd 8 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 803 hits for monomerid = 11639
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 1 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	7.4	25
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Carbonic anhydrase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	21	n/a	n/a	n/a	n/a	7.4	25
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Carbonic anhydrase 4 (Bovine)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	290	n/a	n/a	n/a	n/a	7.4	25
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Carbonic anhydrase 9 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	20
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Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.31E+4	n/a	n/a	n/a	n/a	8.0	37
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Prostaglandin G/H synthase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	70	n/a	n/a	n/a	n/a	8.0	37
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Putative hydrolase (Pseudomonas aeruginosa (strain UCBPP-PA14))	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Bifunctional epoxide hydrolase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cell division control protein 42 homolog (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Cell division control protein 42 homolog (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Ras-related protein Rab-7a (Dog)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Ras-related protein Rab-2A (Dog)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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GTPase KRas [1-37] (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Ras-related C3 botulinum toxin substrate 1 (Mouse)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	4.31E+4	n/a	n/a	n/a	n/a
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GTPase KRas [1-37] (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Ras-related C3 botulinum toxin substrate 1 (Mouse)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 [582-599] (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 [582-599] (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
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3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	37
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Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	37
TBA								Citation and Details
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Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	8.0	25
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	220	n/a	n/a	n/a	n/a	8.0	25
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Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 2 [E165G] (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 2 [E165G] (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.83E+4	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	789	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Polyunsaturated fatty acid 5-lipoxygenase (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.48E+4	n/a	n/a	n/a	n/a	8.0	25
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	50	n/a	n/a	n/a	n/a	8.0	25
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.05E+4	n/a	n/a	n/a	n/a	8.0	37
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Sheep)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	90	n/a	n/a	n/a	n/a	8.0	37
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cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Human)	BDBM11639 (Celecoxib \| CLX \| Celebrex \| 4-[5-(4-methylphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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