BDBM11863 4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N-hydroxyoxane-4-carboxamide::CHEMBL440498::RS 130830::RS-130,830::alpha-tetrahydropyran beta-sulfone 1B

SMILES: c1cc(ccc1Oc2ccc(cc2)Cl)S(=O)(=O)CC3(CCOCC3)C(=O)NO

InChI Key: InChIKey=ROSNVSQTEGHUKU-UHFFFAOYSA-N

Data: 18 KI  46 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 11863   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interstitial collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrilysin (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neutrophil collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-2 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-2 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neutrophil collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrilysin (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-1 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-1 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-2 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neutrophil collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neutrophil collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-2 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interstitial collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-1 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrilysin (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interstitial collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	356	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-1 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interstitial collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interstitial collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interstitial collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	233	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		0.280	-12.9	0.300	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Collagenase 3 (Human)	BDBM11863 (CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...) Show SMILES Show InChI	GoogleScholar	UniChem		0.520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair