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BDBM120336 US8703811, 78

SMILES: Cc1nc2ccccc2n1-c1cc(cs1)C(=O)NC1CC1

InChI Key: InChIKey=FBLLYJXHZSEJAR-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120336   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM120336
PNG
(US8703811, 78)
Show SMILES Cc1nc2ccccc2n1-c1cc(cs1)C(=O)NC1CC1
Show InChI InChI=1S/C16H15N3OS/c1-10-17-13-4-2-3-5-14(13)19(10)15-8-11(9-21-15)16(20)18-12-6-7-12/h2-5,8-9,12H,6-7H2,1H3,(H,18,20)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...


US Patent US8703811 (2014)


BindingDB Entry DOI: 10.7270/Q2WD3Z7P
More data for this
Ligand-Target Pair