BDBM120816 (Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopropoxy) quinolin-4-yl)oxy)phenyl)amino)methylene)-3-methyl-1-(2- (trifluoromethyl)phenyl)-1H-pyrazol-5(4H)-one (17)

SMILES COc1cc2c(Oc3ccc(cc3F)N=Cc3c(C)[nH]n(-c4ccccc4C(F)(F)F)c3=O)ccnc2cc1OCCCN1CCOCC1

InChI Key InChIKey=KEDANNMRCOENMZ-LLJCYPMUSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 120816   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  2.20nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit [1-973](Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  2.30nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  8.38nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  8.56nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  326nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [1-973](Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  4.24nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha [1-973](Homo sapiens (Human))
Shenyang Pharmaceutical University

LigandPNGBDBM120816((Z)-4-(((3-fluoro-4-((6-methoxy-7-(3-morpholinopro...)
Affinity DataIC50:  32.2nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity was evaluated by homogeneous time-resolved fluorescence (HTRF) assays. In a 384-well plate, 20 µg/mL (Glue, Tyr) 4:1 w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed