BDBM12097 3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 15::N-butyl-3-{2-[4-(pyrrolidin-1-yl)phenyl]acetamido}-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxamide

SMILES CCCCNC(=O)N1Cc2n[nH]c(NC(=O)Cc3ccc(cc3)N3CCCC3)c2C1

InChI Key InChIKey=IPWGWCRUNGLOHK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 12097   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12097(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Affinity DataIC50:  33nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12097(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Affinity DataIC50:  400nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12097(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Affinity DataIC50:  4.20E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12097(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12097(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Affinity DataIC50:  280nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12097(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Affinity DataIC50:  91nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed