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BDBM121003 US8716285, 60

SMILES: ONC(=O)c1ccc2NCC(Cc2c1)NS(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=DWXMCTWQRZOSNV-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 121003   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))
BDBM121003
PNG
(US8716285, 60)
Show SMILES ONC(=O)c1ccc2NCC(Cc2c1)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H16ClN3O4S/c17-12-2-4-14(5-3-12)25(23,24)20-13-8-11-7-10(16(21)19-22)1-6-15(11)18-9-13/h1-7,13,18,20,22H,8-9H2,(H,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.46E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc

US Patent


Assay Description
Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...


US Patent US8716285 (2014)


BindingDB Entry DOI: 10.7270/Q2K072XG
More data for this
Ligand-Target Pair