BDBM12110 1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 18::5-N-(2,6-diethylphenyl)-3-N-[4-(4-methylpiperazin-1-yl)benzene]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-3,5-dicarboxamide::CHEMBL363160::N-(2,6-Diethylphenyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide::PHA-680632

SMILES CCc1cccc(CC)c1NC(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1

InChI Key InChIKey=OBWNXGOQPLDDPS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12110   

TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12110(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 18 | 5-N-...)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12110(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 18 | 5-N-...)
Affinity DataIC50:  27nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM12110(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 18 | 5-N-...)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed