BDBM121324 US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzylamino)-N-(9- chloro-3,3-difluoro-3,4-dihydro- 2H-1,5-benzodioxepin-7- ylmethyl)-N- isobutylpropanamide

SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@H](C)CNCc1cccc(O)c1

InChI Key InChIKey=HCMJCMYVOXIEMD-GOSISDBHSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 121324   

TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents Of The University Of California

US Patent
LigandPNGBDBM121324(US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzyl...)
Affinity DataKi:  0.280nM ΔG°:  -13.5kcal/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents Of The University Of California

US Patent
LigandPNGBDBM121324(US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzyl...)
Affinity DataKi:  0.930nM ΔG°:  -12.8kcal/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProkineticin receptor 1(Cricetulus griseus (Chinese hamster))
The Regents Of The University Of California

US Patent
LigandPNGBDBM121324(US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzyl...)
Affinity DataKi:  1.15nM ΔG°:  -12.7kcal/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
In DepthDetails US Patent