BDBM121390 US8722890, 5

SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cnn(C[C@H](O)CO)c2)cc1

InChI Key InChIKey=BRTHUECZMVKNMQ-FQEVSTJZSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 121390   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  1.83nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  1.45nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  1.34nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  1.22nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Assays (200 μL final volume) were carried out in NUNC polypropylene deep well plates in 50 mM potassium phosphate buffer, pH 7.4, using a microt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  28.9nMpH: 7.4Assay Description:To determine Aurora B activity of representative compounds of the invention, Active Aurora B enzyme (recombinant residues 1-344) and INCENP (recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  570nMpH: 7.4Assay Description:To determine Aurora A and C activity of representative compounds of the invention, Active Aurora A or C enzyme was incubated in wells of a 384 well p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Assays (200 μL final volume) were carried out in NUNC polypropylene deep well plates in 50 mM potassium phosphate buffer, pH 7.4, using a microt...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  12.6nMpH: 7.1 T: 2°CAssay Description:To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...More data for this Ligand-Target Pair
In DepthDetails US Patent