BDBM122537 US8735593, I-5

SMILES Cc1cc(Nc2n[nH]c3ncc(F)cc23)nc(-c2ccccc2)c1C

InChI Key InChIKey=RAUNAZYXRMQIJT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 122537   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM122537(US8735593, I-5)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM122537(US8735593, I-5)
Affinity DataIC50:  20nMpH: 7.5 T: 2°CAssay Description:Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...More data for this Ligand-Target Pair
In DepthDetails US Patent