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BDBM122774 US8735386, I-244

SMILES: CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(Cl)c5)c4-c3n2)n1

InChI Key: InChIKey=XLSZLFIPXJUASQ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 122774   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122774
PNG
(US8735386, I-244)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(Cl)c5)c4-c3n2)n1
Show InChI InChI=1S/C22H22ClN7/c1-3-30-10-9-19(28-30)25-22-24-13-15-7-8-17-20(21(15)26-22)18(29(2)27-17)12-14-5-4-6-16(23)11-14/h4-6,9-11,13H,3,7-8,12H2,1-2H3,(H,24,25,26,28)
PDB
MMDB

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PC sid
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Similars

US Patent
n/an/a 8n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair