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BDBM122885 US8735386, III-47

SMILES: COc1cc(ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(CC1)C1CCOCC1

InChI Key: InChIKey=PWLAKBPKQLBFTJ-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 122885   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122885
PNG
(US8735386, III-47)
Show SMILES COc1cc(ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(CC1)C1CCOCC1
Show InChI InChI=1/C35H40ClN7O3/c1-21-18-29-31(33(42(2)41-29)25-6-4-5-7-27(25)36)32-26(21)20-37-35(40-32)39-28-9-8-22(19-30(28)45-3)34(44)38-23-10-14-43(15-11-23)24-12-16-46-17-13-24/h4-9,19-21,23-24H,10-18H2,1-3H3,(H,38,44)(H,37,39,40)
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Similars

US Patent
n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair