BDBM12342 2H-chromen-2-one::CHEMBL6466::Coumarin

SMILES: c1ccc2c(c1)C=CC(=O)O2

InChI Key: InChIKey=ZYGHJZDHTFUPRJ-UHFFFAOYSA-N

Data: 56 KI  17 IC50

PDB links: 11 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 75 hits for monomerid = 12342   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
UDP-glucuronosyltransferase 1A1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Amine oxidase [flavin-containing] A (Rat)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Amine oxidase [flavin-containing] B (Rat)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (Trypanosoma cruzi)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.92E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Sorbitol dehydrogenase (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Aldo-keto reductase family 1 member B1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Exportin-1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Sclerostin (Homo sapiens)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	231	n/a	n/a	n/a	n/a	n/a
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Sclerostin (Homo sapiens)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	273	n/a	n/a	n/a	n/a	n/a
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Glyceraldehyde-3-phosphate dehydrogenase (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.92E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydroorotate dehydrogenase (fumarate) (Leishmania major)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.42E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (fumarate) (Leishmania major)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.31E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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UDP-glucuronosyltransferase 2B10 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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UDP-glucuronosyltransferase 1A4 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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UDP-glucuronosyltransferase 2B7 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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UDP-glucuronosyltransferase 1-6 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 14 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 9 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Zn finger protein (Common tobacco)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 6 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 7 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		4.06E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 5B, mitochondrial (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 3 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 4 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 12 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 9 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 13 (Mouse)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Acetylcholinesterase (Mouse)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.30E+3	-6.86	n/a	n/a	n/a	n/a	n/a	7.0	25
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Carbonic anhydrase 5A, mitochondrial (Human)	BDBM12342 (2H-chromen-2-one | CHEMBL6466 | Coumarin) Show SMILES Show InChI	GoogleScholar	UniChem		9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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