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BDBM124059 US8754233, 5-Methyl-4-(6-pyrrolidin-1-ylmethyl-benzothiazol-2-yl)-2H-pyrazol-3-ylamine

SMILES: Cc1[nH]nc(N)c1-c1nc2ccc(CN3CCCC3)cc2s1

InChI Key: InChIKey=HUKMBIBKVQGNFM-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124059   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase ILK-1


(Homo sapiens (Human))
BDBM124059
PNG
(US8754233, 5-Methyl-4-(6-pyrrolidin-1-ylmethyl-ben...)
Show SMILES Cc1[nH]nc(N)c1-c1nc2ccc(CN3CCCC3)cc2s1
Show InChI InChI=1S/C16H19N5S/c1-10-14(15(17)20-19-10)16-18-12-5-4-11(8-13(12)22-16)9-21-6-2-3-7-21/h4-5,8H,2-3,6-7,9H2,1H3,(H3,17,19,20)
PDB
MMDB

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Similars

US Patent
n/an/a 900n/an/an/an/an/a40



Dermira (Canada), Inc.

US Patent


Assay Description
5 uL of each compound dilution were robotically pipetted to Costar serocluster plates maintaining the same plate layout. All assay mixtures consisted...


US Patent US8754233 (2014)


BindingDB Entry DOI: 10.7270/Q23N2231
More data for this
Ligand-Target Pair