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BDBM124078 US8754089, 3-(3-fluorophenyl)-6-methyl-2-((9H-purin-6-ylamino)methyl)-4H-pyrido[1,2-a]pyrimidin-4-one

SMILES: Cc1cccc2nc(CNc3ncnc4[nH]cnc34)c(-c3cccc(F)c3)c(=O)n12

InChI Key: InChIKey=NQXZSJKCRANMSZ-UHFFFAOYSA-N

Data: 1 KI

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124078   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM124078
PNG
(US8754089, 3-(3-fluorophenyl)-6-methyl-2-((9H-puri...)
Show SMILES Cc1cccc2nc(CNc3ncnc4[nH]cnc34)c(-c3cccc(F)c3)c(=O)n12
Show InChI InChI=1S/C21H16FN7O/c1-12-4-2-7-16-28-15(9-23-19-18-20(25-10-24-18)27-11-26-19)17(21(30)29(12)16)13-5-3-6-14(22)8-13/h2-8,10-11H,9H2,1H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

US Patent
711n/an/an/an/an/an/a7.0n/a



Amgen Inc

US Patent


Assay Description
A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...


US Patent US8754089 (2014)


BindingDB Entry DOI: 10.7270/Q2ZW1JMB
More data for this
Ligand-Target Pair