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BDBM124102 US8754089, 7-fluoro-3-(3-fluorophenyl)-2-((1R)-1-(9H-purin-6-ylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

SMILES: C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cn2c(=O)c1-c1cccc(F)c1

InChI Key: InChIKey=RRTVCOAJMKLHDG-LLVKDONJSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124102   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM124102
PNG
(US8754089, 7-fluoro-3-(3-fluorophenyl)-2-((1R)-1-(...)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cn2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C21H15F2N7O/c1-11(28-20-18-19(25-9-24-18)26-10-27-20)17-16(12-3-2-4-13(22)7-12)21(31)30-8-14(23)5-6-15(30)29-17/h2-11H,1H3,(H2,24,25,26,27,28)/t11-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

US Patent
1.98E+4n/an/an/an/an/an/a7.0n/a



Amgen Inc

US Patent


Assay Description
A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...


US Patent US8754089 (2014)


BindingDB Entry DOI: 10.7270/Q2ZW1JMB
More data for this
Ligand-Target Pair