BindingDB logo
myBDB logout

BDBM124430 US8759532, 83

SMILES: Cn1c(Nc2ccc(Oc3ncccc3-c3cccnc3)cc2)nc2ccccc12

InChI Key: InChIKey=XYAIATPPEDVOPO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124430   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM124430
PNG
(US8759532, 83)
Show SMILES Cn1c(Nc2ccc(Oc3ncccc3-c3cccnc3)cc2)nc2ccccc12
Show InChI InChI=1S/C24H19N5O/c1-29-22-9-3-2-8-21(22)28-24(29)27-18-10-12-19(13-11-18)30-23-20(7-5-15-26-23)17-6-4-14-25-16-17/h2-16H,1H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.249n/an/an/an/an/a25



Amgen Inc

US Patent


Assay Description
To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...


US Patent US8759532 (2014)


BindingDB Entry DOI: 10.7270/Q25D8QHR
More data for this
Ligand-Target Pair