BDBM125487 US8772480, 351

SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)C(OC(=O)c2cccc(Cl)c2)C(C)(C)O)cc1F

InChI Key InChIKey=NZXIRKWJXSSTSF-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 125487   

LigandChemical structure of BindingDB Monomer ID 125487BDBM125487(US8772480, 351)
Affinity DataKi:  9nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 125487BDBM125487(US8772480, 351)
Affinity DataIC50: 1.00E+4nMAssay Description:The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent