BDBM12578 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid::Bisphosphonate 3::CGP-42446::CHEMBL924::JMC515594 Compound 55::Reclast::US11279719, Example Zolendronic acid (ZOL)::ZOL::Zoledronate::Zometa::[1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid::zoledronic acid

SMILES: c1cn(cn1)CC(O)(P(=O)(O)O)P(=O)(O)O

InChI Key: InChIKey=XRASPMIURGNCCH-UHFFFAOYSA-N

Data: 7 KI  66 IC50  5 EC50  2 ITC

PDB links: 20 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 78 hits for monomerid = 12578   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl pyrophosphate synthase BTS1 (Baker's yeast)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	475	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	475	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
H(+)-exporting diphosphatase (Trypanosoma brucei)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.27E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Butyrophilin subfamily 3 member A1 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.06E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 14 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polyprenyl synthetase family protein (Leishmania donovani)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 14 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Butyrophilin subfamily 3 member A1 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	7.90E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Butyrophilin subfamily 3 member A1 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Butyrophilin subfamily 3 member A1 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl diphosphate synthase (Escherichia coli (strain K12))	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Butyrophilin subfamily 3 member A1 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	487	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Human)	BDBM12578 (CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phos...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair