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BDBM126414 US8778951, 224

SMILES: N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cnc(C(N)=O)c(NCC2CCOCC2)n1

InChI Key: InChIKey=ZAEIYTFBEOFDOU-SHTZXODSNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126414   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-T1


(Homo sapiens (Human))
BDBM126414
PNG
(US8778951, 224)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cnc(C(N)=O)c(NCC2CCOCC2)n1
Show InChI InChI=1/C22H30ClN7O2/c23-17-11-26-19(29-15-3-1-14(24)2-4-15)9-16(17)18-12-27-20(21(25)31)22(30-18)28-10-13-5-7-32-8-6-13/h9,11-15H,1-8,10,24H2,(H2,25,31)(H,26,29)(H,28,30)/t14-,15-
PDB
MMDB

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PC sid
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Similars

US Patent
n/an/a 0.0919n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...


US Patent US8778951 (2014)


BindingDB Entry DOI: 10.7270/Q25B014T
More data for this
Ligand-Target Pair