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BDBM126499 US8778951, 309

SMILES: COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1C(F)(F)F

InChI Key: InChIKey=WWTWYISYTASUMK-NQDYJFDNNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126499   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-T1


(Homo sapiens (Human))
BDBM126499
PNG
(US8778951, 309)
Show SMILES COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NCC2CCOCC2)ccc1C(F)(F)F
Show InChI InChI=1/C27H37ClF3N5O2/c1-17(16-37-2)34-19-3-5-20(6-4-19)35-25-13-21(23(28)15-33-25)26-22(27(29,30)31)7-8-24(36-26)32-14-18-9-11-38-12-10-18/h7-8,13,15,17-20,34H,3-6,9-12,14,16H2,1-2H3,(H,32,36)(H,33,35)/t17-,19-,20-/s2
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Similars

US Patent
n/an/a 0.0350n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...


US Patent US8778951 (2014)


BindingDB Entry DOI: 10.7270/Q25B014T
More data for this
Ligand-Target Pair