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BDBM126516 US8778951, 327

SMILES: COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NC[C@H]2CCCOC2)ccc1Cl

InChI Key: InChIKey=SQFDOWFJUZXLIH-WPZZULIINA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126516   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-T1


(Homo sapiens (Human))
BDBM126516
PNG
(US8778951, 327)
Show SMILES COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1nc(NC[C@H]2CCCOC2)ccc1Cl
Show InChI InChI=1/C26H37Cl2N5O2/c1-17(15-34-2)31-19-5-7-20(8-6-19)32-25-12-21(23(28)14-30-25)26-22(27)9-10-24(33-26)29-13-18-4-3-11-35-16-18/h9-10,12,14,17-20,31H,3-8,11,13,15-16H2,1-2H3,(H,29,33)(H,30,32)/t17-,18-,19-,20-/s2
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MMDB

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PC sid
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Similars

US Patent
n/an/a 0.00100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...


US Patent US8778951 (2014)


BindingDB Entry DOI: 10.7270/Q25B014T
More data for this
Ligand-Target Pair