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BDBM126517 US8778951, 328

SMILES: COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@H]2CCOC(C)(C)C2)n1

InChI Key: InChIKey=NROKDTDCYXNXSQ-ZOXNGFNYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126517   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-T1


(Homo sapiens (Human))
BDBM126517
PNG
(US8778951, 328)
Show SMILES COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NC[C@H]2CCOC(C)(C)C2)n1
Show InChI InChI=1/C28H42ClN5O2/c1-19(18-35-4)32-21-8-10-22(11-9-21)33-27-14-23(24(29)17-31-27)25-6-5-7-26(34-25)30-16-20-12-13-36-28(2,3)15-20/h5-7,14,17,19-22,32H,8-13,15-16,18H2,1-4H3,(H,30,34)(H,31,33)/t19-,20+,21-,22-/s2
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MMDB

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Similars

US Patent
n/an/a 0.00100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...


US Patent US8778951 (2014)


BindingDB Entry DOI: 10.7270/Q25B014T
More data for this
Ligand-Target Pair