BDBM12657 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsulfonyl)-[1,1-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::1-[3-(aminomethyl)phenyl]-N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::CHEMBL559015::DPC 423::DPC423

SMILES: CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2cccc(CN)c2)C(F)(F)F)c(F)c1

InChI Key: InChIKey=ZLUOAFAJSUPHOG-UHFFFAOYSA-N

Data: 36 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 12657   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Trypsin (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Prothrombin (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
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Complement factor H (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.150	-13.3	n/a	n/a	n/a	n/a	n/a	7.0	22
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Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	-12.9	n/a	n/a	n/a	n/a	n/a	7.0	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine protease 1/Trypsin-2 (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine protease 1 (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine protease 1 (Bovine)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Plasma kallikrein (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Plasma kallikrein (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Plasma kallikrein (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coagulation factor X (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Vitamin K-dependent protein C (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Vitamin K-dependent protein C (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor IX (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Coagulation factor IX (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Coagulation factor IX (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Prothrombin (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Prothrombin (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prothrombin (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prothrombin (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prothrombin (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coagulation factor VII (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coagulation factor VII (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coagulation factor VII (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Chymotrypsinogen B (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Chymotrypsinogen B (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Urokinase-type plasminogen activator (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Plasminogen (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Plasminogen (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Tissue-type plasminogen activator (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Human)	BDBM12657 (CHEMBL559015 | 1-[3-(Aminomethyl)phenyl]-N-[3-fluo...) Show SMILES Show InChI	GoogleScholar	UniChem		>4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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