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BDBM126592 US8772283, 36

SMILES: CC1(O)CC(N)(C1)c1ccc(cc1)-c1nc2-c3ccncc3OCn2c1-c1ccccc1

InChI Key: InChIKey=CGZPNBUBJPIWBN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 126592   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM126592
PNG
(US8772283, 36)
Show SMILES CC1(O)CC(N)(C1)c1ccc(cc1)-c1nc2-c3ccncc3OCn2c1-c1ccccc1
Show InChI InChI=1S/C26H24N4O2/c1-25(31)14-26(27,15-25)19-9-7-17(8-10-19)22-23(18-5-3-2-4-6-18)30-16-32-21-13-28-12-11-20(21)24(30)29-22/h2-13,31H,14-16,27H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.740n/an/an/an/a7.5n/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM126592
PNG
(US8772283, 36)
Show SMILES CC1(O)CC(N)(C1)c1ccc(cc1)-c1nc2-c3ccncc3OCn2c1-c1ccccc1
Show InChI InChI=1S/C26H24N4O2/c1-25(31)14-26(27,15-25)19-9-7-17(8-10-19)22-23(18-5-3-2-4-6-18)30-16-32-21-13-28-12-11-20(21)24(30)29-22/h2-13,31H,14-16,27H2,1H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.5n/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
Preparation of AKT1 and AKT2 and measurement of in vitro inhibitory activity of the above-mentioned compounds against AKT1 and AKT2 kinase activity w...


US Patent US8772283 (2014)


BindingDB Entry DOI: 10.7270/Q21J98F0
More data for this
Ligand-Target Pair