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BDBM1273 L-682, 679 analog 32::tert-butyl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-5-{[(1S)-1-[(2-hydroxyethyl)carbamoyl]-3-methylbutyl]carbamoyl}-1-phenylpentan-2-yl]carbamate

SMILES: CC(C)C[C@H](NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)NCCO

InChI Key: InChIKey=HXCJNPQEJMWFOR-UNFRKHOWSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1273   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Protease


(Human immunodeficiency virus type 1)
BDBM1273
PNG
(L-682, 679 analog 32 | tert-butyl N-[(2S,3S,5R)-5-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C32H47N3O6/c1-22(2)18-27(30(39)33-16-17-36)34-29(38)25(19-23-12-8-6-9-13-23)21-28(37)26(20-24-14-10-7-11-15-24)35-31(40)41-32(3,4)5/h6-15,22,25-28,36-37H,16-21H2,1-5H3,(H,33,39)(H,34,38)(H,35,40)/t25-,26+,27+,28+/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10n/an/an/an/a5.530



Merck Sharp and Dohme Research Laboratories



Assay Description
Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...


J Med Chem 34: 2852-7 (1991)


Article DOI: 10.1021/jm00113a025
BindingDB Entry DOI: 10.7270/Q2M906TJ
More data for this
Ligand-Target Pair