BDBM127447 US8791131, 221

SMILES O=c1n(CCO)c2cnc3ccc(-c4cn[nH]c4)nc3c2n1C1CCOCC1

InChI Key InChIKey=YOFCCRUHRZFAHE-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127447   

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 127447BDBM127447(US8791131, 221)
Affinity DataKi:  15.7nM ΔG°:  -10.6kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent