BDBM127450 US8791131, 224

SMILES COc1ncc(cn1)-c1ccc2ncc3n(CCO)c(=O)n(C4CCOCC4)c3c2n1

InChI Key InChIKey=BQPUXKTVCMVYHE-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127450   

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 127450BDBM127450(US8791131, 224)
Affinity DataKi:  229nM ΔG°:  -9.05kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent