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BDBM127880 US8791130, 10

SMILES: CNc1nc(Nc2ccc(cc2OC)-c2nnnn2C)ncc1Cl

InChI Key: InChIKey=QKXAPQQKFYTTDM-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127880   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM127880
PNG
(US8791130, 10)
Show SMILES CNc1nc(Nc2ccc(cc2OC)-c2nnnn2C)ncc1Cl
Show InChI InChI=1S/C14H15ClN8O/c1-16-12-9(15)7-17-14(19-12)18-10-5-4-8(6-11(10)24-3)13-20-21-22-23(13)2/h4-7H,1-3H3,(H2,16,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8791130 (2014)


BindingDB Entry DOI: 10.7270/Q2K9367R
More data for this
Ligand-Target Pair