BDBM128101 US10206907, Compound 330::US8796457, 1::US9505754, 1

SMILES CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12

InChI Key InChIKey=MPYACSQFXVMWNO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 128101   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50:  6.60nMT: 2°CAssay Description:Recombinant human JAK1 (catalytic domain, amino acids 866-1154; catalog number PV4774) was purchased from Invitrogen. 1 ng of JAK1 was incubated with...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50:  6.60nMT: 2°CAssay Description:Recombinant human JAK1 (catalytic domain, amino acids 866-1154; catalog number PV4774) was purchased from Invitrogen. 1 ng of JAK1 was incubated with...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [866-1054](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50:  67nMT: 2°CAssay Description:Recombinant human JAK2 (catalytic domain, amino acids 866-1154; catalog number PV4210) was purchased from Invitrogen. 0.0125 mU of JAK2 was incubated...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [850-1154](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50: <100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [871-1187](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50:  219nMpH: 7.5 T: 2°CAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50:  300nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50: <100nMAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM128101(US10206907, Compound 330 | US8796457, 1 | US950575...)
Affinity DataIC50:  408nMpH: 7.5 T: 2°CAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent