BDBM128295 US8796284, 1

SMILES Nc1nc(nc(c1Br)-n1cccn1)-n1cccn1

InChI Key InChIKey=ATFXVNUWQOXRRU-UHFFFAOYSA-N

Data  7 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 128295   

TargetAdenosine receptor A2a(Human)
Palobiofarma

US Patent
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  12nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Palobiofarma

US Patent
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]ZM241385 from human adenosine 2A receptor transfected in human HeLa cells incubated for 30 mins by competition radioligand bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Palobiofarma

US Patent
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  25nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:hese assays were performed at adenosine receptors transfected using a cAMP enzymeimmunoassay kit (Amersham Biosciences). CHO-A2A cells were seeded (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Palobiofarma

US Patent
LigandPNGBDBM128295(US8796284, 1)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at adenosine 2A receptor (unknown origin) expressed in CHO cells assessed as reduction in intracellular cAMP level preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Palobiofarma

US Patent
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  50nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  1.00E+3nMAssay Description:Antagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  2.50E+3nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in CHO cells by radioligand competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  5.00E+3nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in HeLa cells by radioligand competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed