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BDBM128370 US8802861, 7

SMILES: CC(=O)Nc1nc(C)c(s1)-c1csc(Nc2cccnc2)n1

InChI Key: InChIKey=NUTDKFGHUBYHFK-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128370   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM128370
PNG
(US8802861, 7)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1csc(Nc2cccnc2)n1
Show InChI InChI=1S/C14H13N5OS2/c1-8-12(22-14(16-8)17-9(2)20)11-7-21-13(19-11)18-10-4-3-5-15-6-10/h3-7H,1-2H3,(H,18,19)(H,16,17,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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DrugBank
antibodypedia
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PC cid
PC sid
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Similars

US Patent
n/an/a 94n/an/an/an/an/an/a



Merck Serono

US Patent


Assay Description
The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...


US Patent US8802861 (2014)


BindingDB Entry DOI: 10.7270/Q2HD7TCX
More data for this
Ligand-Target Pair