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BDBM128508 US8796244, 87

SMILES: FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnc(nc1)N1CC(F)(F)C1

InChI Key: InChIKey=GXICWTBOIKQMNI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 128508   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM128508
PNG
(US8796244, 87)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnc(nc1)N1CC(F)(F)C1
Show InChI InChI=1S/C23H18F5N7O/c24-22(25)12-34(13-22)20-30-8-16(9-31-20)14-4-5-35-18(10-29-19(35)7-14)15-2-1-3-17(6-15)33-21(36)32-11-23(26,27)28/h1-10H,11-13H2,(H2,32,33,36)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 230n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
VEGFR2 (from Upstate), prepared at 2x final concentration, was incubated with test compounds, biotinylated Flt3 substrate (biotin-VASSDNEYFYVDF) (Cel...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128508
PNG
(US8796244, 87)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnc(nc1)N1CC(F)(F)C1
Show InChI InChI=1S/C23H18F5N7O/c24-22(25)12-34(13-22)20-30-8-16(9-31-20)14-4-5-35-18(10-29-19(35)7-14)15-2-1-3-17(6-15)33-21(36)32-11-23(26,27)28/h1-10H,11-13H2,(H2,32,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 13n/an/an/an/a8.025



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)


BindingDB Entry DOI: 10.7270/Q20C4TFP
More data for this
Ligand-Target Pair