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BDBM130010 US8815926, 291

SMILES: COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)cc(=O)n2C)c(OC)n1

InChI Key: InChIKey=KEIMAURQUMCKHJ-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130010   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM130010
PNG
(US8815926, 291)
Show SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)cc(=O)n2C)c(OC)n1
Show InChI InChI=1/C27H27ClN6O4/c1-14(2)33-23-21(30-24(33)18-13-29-27(38-6)31-25(18)37-5)26(36)34(19-11-15(3)12-20(35)32(19)4)22(23)16-7-9-17(28)10-8-16/h7-14,22H,1-6H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.41n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...


US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair