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BDBM130827 US8829199, 68

SMILES: CCCCc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1

InChI Key: InChIKey=SOLHEZQXFSKDQL-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 130827   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM130827
PNG
(US8829199, 68)
Show SMILES CCCCc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C24H24N6O/c1-3-4-5-15-6-7-16-11-22(29-20(16)10-15)23(31)18-13-26-30(24(18)25)17-8-9-19-21(12-17)28-14(2)27-19/h6-13,29H,3-5,25H2,1-2H3,(H,27,28)
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Similars

US Patent
n/an/a 230n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130827
PNG
(US8829199, 68)
Show SMILES CCCCc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C24H24N6O/c1-3-4-5-15-6-7-16-11-22(29-20(16)10-15)23(31)18-13-26-30(24(18)25)17-8-9-19-21(12-17)28-14(2)27-19/h6-13,29H,3-5,25H2,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt

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antibodypedia
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PC sid
UniChem

Similars

US Patent
n/an/a 400n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM130827
PNG
(US8829199, 68)
Show SMILES CCCCc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C24H24N6O/c1-3-4-5-15-6-7-16-11-22(29-20(16)10-15)23(31)18-13-26-30(24(18)25)17-8-9-19-21(12-17)28-14(2)27-19/h6-13,29H,3-5,25H2,1-2H3,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 200n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair