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BDBM130828 US8829199, 69

SMILES: Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2cnn(C)c2)c1N

InChI Key: InChIKey=QSTFLZOOJVWRBM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 130828   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM130828
PNG
(US8829199, 69)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2cnn(C)c2)c1N
Show InChI InChI=1S/C24H20N8O/c1-13-28-19-6-5-17(9-21(19)29-13)32-24(25)18(11-27-32)23(33)22-8-15-4-3-14(7-20(15)30-22)16-10-26-31(2)12-16/h3-12,30H,25H2,1-2H3,(H,28,29)
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Similars

US Patent
n/an/a 23n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130828
PNG
(US8829199, 69)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2cnn(C)c2)c1N
Show InChI InChI=1S/C24H20N8O/c1-13-28-19-6-5-17(9-21(19)29-13)32-24(25)18(11-27-32)23(33)22-8-15-4-3-14(7-20(15)30-22)16-10-26-31(2)12-16/h3-12,30H,25H2,1-2H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM130828
PNG
(US8829199, 69)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2cnn(C)c2)c1N
Show InChI InChI=1S/C24H20N8O/c1-13-28-19-6-5-17(9-21(19)29-13)32-24(25)18(11-27-32)23(33)22-8-15-4-3-14(7-20(15)30-22)16-10-26-31(2)12-16/h3-12,30H,25H2,1-2H3,(H,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair